Professor Yuan Liu, a faculty member of the Biomolecular Sciences Institute (BSI), was recently granted a U.S. Patent (Patent No. US 9809843 B1) for her invention of a high throughput measurement of DNA base lesion repair capacity in human cell and tissue.
This novel fluorescence-based technology features a simple, fast, accurate and high throughput measurement of DNA base lesion repair capacity in cell and tissue lysates. The technology can be applied for high-throughput measurement of base lesion repair capacity of cells obtained from human population studies and patient tissue, and allows for screenings of anti-cancer drugs and environmental toxicants that can inhibit base excision repair pathways for disease prevention as well as for monitoring of DNA repair at specific genes and genome sequences as a biomarker for personal medicine and precision medicine.
The technology has been recently applied for screening DNA base lesion repair inhibitors in human prostate cancer cells and successfully identified novel compounds that can significantly suppress prostate cancer progression.
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